(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide
CAS No.:1334404-44-2
Molecular Formula:C₃₂H₄₃NO₅SSi
Molecular Weight:581.849
Hs Code.:

Synonyms:(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

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Chemical Property of (R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

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Technology Process of (R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

There total 5 articles about (R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (R)-2-(((tert-butyl)diphenylsilanoxy)ethyl)-1-(toluene-4-sulfonyl)aziridine

: 37610-80-3
1,3-dioxolan-2-ylethylmagnesium bromide

: 1334404-44-2
(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

Guidance literature:: 1,3-dioxolan-2-ylethylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In 2,3-dimercapto-succinic acid; at -78 ℃; for 1h;

(R)-2-(((tert-butyl)diphenylsilanoxy)ethyl)-1-(toluene-4-sulfonyl)aziridine; In tetrahydrofuran; 2,3-dimercapto-succinic acid; at -78 - 20 ℃;
DOI:10.1039/c1cc13048j

Reference yield:

: N-(3-hydroxy-1-hydroxymethylpropyl)-4-methylbenzenesulfonamide

: 1334404-44-2
(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C

2.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C

3.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C

3.2: -78 - 20 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 2,3-dimercapto-succinic acid; toluene; 1.1: Mitsunobu reaction;
DOI:10.1039/c1cc13048j

Reference yield:

: 934472-06-7
2-hydroxyethyl-1-(toluene-4-sulfonyl)aziridine

: 1334404-44-2
(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C

2.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C

2.2: -78 - 20 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; 2,3-dimercapto-succinic acid;
DOI:10.1039/c1cc13048j