(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

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Chemical Name:(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate
CAS No.:1408065-37-1
Molecular Formula:C₃₈H₅₀N₂O₈S
Molecular Weight:694.89
Hs Code.:

Synonyms:(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

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Chemical Property of (S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

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Technology Process of (S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

There total 6 articles about (S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1408065-19-9
C₂₁H₃₆N₂O₄S

: 42973-19-3
(4-Benzyloxycarbonylmethyl-phenoxy)-acetic acid

: 1408065-37-1
(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 120h; Inert atmosphere;
DOI:10.1039/c2ob26103k

Reference yield:

: 166954-03-6
benzyl 4-(2-tert-butoxy-2-oxoethoxy)phenylacetate

: 1408065-37-1
(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 120 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2ob26103k

Reference yield:

: 5978-22-3,1426213-63-9
N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride

: 1408065-37-1
(S)-tert-butyl 6-(2-(4-(2-benzyloxy-2-oxoethyl)phenoxy)acetamido)-2-(N-isobutyl-4-methylphenylsulfonamido)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; sodium cyanoborohydride / methanol / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C / Inert atmosphere

3: 10% Pd/C; hydrogen / ethyl acetate / 24 h / 20 °C / 760.05 Torr

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 120 h / 20 °C / Inert atmosphere

With dmap; 10% Pd/C; hydrogen; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1039/c2ob26103k