dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Name:dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate
CAS No.:218629-16-4
Molecular Formula:C₂₀H₂₂N₂O₆
Molecular Weight:386.404
Hs Code.:

Synonyms:dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Property of dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Technology Process of dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

There total 2 articles about dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5600-63-5
4-(4-nitrophenyl)butanoyl chloride

: 218629-16-4
dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / diethyl ether / 2 h / 5 - 20 °C

2: Ac₂O / 2 h / 130 - 140 °C

With sodium hydroxide; acetic anhydride; In diethyl ether;
DOI:10.1021/jm9803119

Reference yield:

: 762-42-5
dimethyl acetylenedicarboxylate

: 138909-46-3
(S)-1-<4-(4-nitrophenyl)butyryl>pyrrolidine-2-carboxylic acid

: 218629-16-4
dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: With acetic anhydride; at 130 - 140 ℃; for 2h; Yield given;
DOI:10.1021/jm9803119

Reference yield: 95.0%

: 218629-16-4
dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

: 218629-17-5
dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: With hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 2h; under 3102.89 Torr;
DOI:10.1021/jm9803119