[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

Base Information

Chemical Name:[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester
CAS No.:1003314-25-7
Molecular Formula:C₂₆H₃₁N₂O₅PS
Molecular Weight:514.582
Hs Code.:

Synonyms:[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

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Chemical Property of [4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

Chemical Property:

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Technology Process of [4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

There total 2 articles about [4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 1003314-24-6
4-(ethoxy-methyl-phosphinoylmethyl)-benzoic acid

: 1003314-25-7
[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 1003313-84-5
1,1-dimethylethyl [2-({[4-(bromomethyl)phenyl]carbonyl}amino)-4-(2-thienyl)phenyl]carbamate

: 89034-24-2
methylphosphinic acid ethyl ester

: 1003314-25-7
[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

Guidance literature:: In toluene; Heating;
DOI:10.1016/j.bmcl.2009.02.009

Reference yield:

: 1003314-25-7
[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester

: 1003314-29-1
[4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid

Guidance literature:: [4-(2-tert-butoxycarbonylamino-5-thiophen-2-yl-phenylcarbamoyl)benzyl]-methyl-phosphinic acid ethyl ester; With sodium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; water;