ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

Base Information

• Chemical Name: ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate
• CAS No.: 1416134-58-1
• Molecular Formula: C₁₅H₂₇NO₆S
• Molecular Weight: 349.448
• Mol file: 1416134-58-1.mol

Synonyms:ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

Chemical Property of ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

There total 3 articles about ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

dimethyl sulfoxide (67-68-5,8070-53-9) + (S)-ethyl N-tert-butoxycarbonylpyroglutamate (144978-35-8,144978-12-1,251924-83-1) → ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate (1416134-58-1)

Guidance literature:

dimethyl sulfoxide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

With trimethyl sulfoxide; In tetrahydrofuran; at 0 - 10 ℃; for 1h;

(S)-ethyl N-tert-butoxycarbonylpyroglutamate; In tetrahydrofuran; at -15 - -10 ℃; for 2h;

Reference yield: 89.3%

trimethyl sulfoxide + (S)-ethyl N-tert-butoxycarbonylpyroglutamate (144978-35-8,144978-12-1,251924-83-1) → ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate (1416134-58-1)

Guidance literature:

trimethyl sulfoxide; With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 10 ℃; for 1h;

(S)-ethyl N-tert-butoxycarbonylpyroglutamate; In tetrahydrofuran; dimethyl sulfoxide; at -15 - -10 ℃; for 2h;

Reference yield: 80.0%

trimethylsulfoxonium iodide (1774-47-6) + (S)-ethyl N-tert-butoxycarbonylpyroglutamate (144978-35-8,144978-12-1,251924-83-1) → ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate (1416134-58-1)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 1h;

(S)-ethyl N-tert-butoxycarbonylpyroglutamate; In dimethyl sulfoxide; at 20 ℃;

upstream raw materials:

trimethylsulfoxonium iodide

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

dimethyl sulfoxide

Downstream raw materials:

C₂₀H₂₉ClN₂O₅

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt