7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Chemical Name:7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one
CAS No.:187949-44-6
Molecular Formula:C₃₀H₃₀F₂N₈O₂
Molecular Weight:572.617
Hs Code.:

Synonyms:7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Chemical Property of 7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Technology Process of 7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

There total 6 articles about 7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 187949-43-5
3-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-7-[4-(4-nitro-phenyl)-piperazin-1-yl]-3H-quinazolin-4-one

: 187949-44-6
7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; chloroform; for 24h; under 760 Torr;
DOI:10.1021/jm9707277

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 187949-44-6
7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 5N aq. HCl / dioxane; various solvent(s) / 18 h / 110 °C

3: 57 percent / various solvent(s) / 120 °C

4: 100 percent / H₂ / 5percent Pd/C / ethanol; CHCl₃ / 24 h / 760 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277

Reference yield:

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 187949-44-6
7-[4-(4-Amino-phenyl)-piperazin-1-yl]-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 5N aq. HCl / dioxane; various solvent(s) / 18 h / 110 °C

3: 57 percent / various solvent(s) / 120 °C

4: 100 percent / H₂ / 5percent Pd/C / ethanol; CHCl₃ / 24 h / 760 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277