methyl α-hydrazonophenylacetate

Base Information

• Chemical Name: methyl α-hydrazonophenylacetate
• CAS No.: 23102-11-6
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.191
• Mol file: 23102-11-6.mol

Synonyms:methyl α-hydrazonophenylacetate

Chemical Property of methyl α-hydrazonophenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α-hydrazonophenylacetate

There total 2 articles about methyl α-hydrazonophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) → methyl α-hydrazonophenylacetate (23102-11-6) + methyl α-phenyl-α-((phenyl(methoxycarbonyl)methylene)hydrazono)acetate (72410-77-6)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In methanol; for 4h; Ambient temperature;

DOI:10.1021/jo00385a029

Reference yield: 40.0%

Methyl phenyldiazoacetate (22979-35-7) → methyl α-hydrazonophenylacetate (23102-11-6)

Guidance literature:

With o-phenylenebis(diphenylphosphine); potassium tert-butylate; water; copper diacetate; bis(pinacol)diborane; In 1,4-dioxane; at 40 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/C8CC07764A

Reference yield: 95.0%

C18H16ClNO4S (1451010-20-0) + methyl α-hydrazonophenylacetate (23102-11-6) + isopropyl alcohol (67-63-0,8013-70-5) → dimethyl (Z)-4-(4-chlorophenyl)-5-isopropoxy-2-(4-methylphenylsulfonamido)-5-phenylhex-2-enedioate

Guidance literature:

C₁₈H₁₆ClNO₄S; isopropyl alcohol; With dirhodium tetraacetate; In dichloromethane; at 25 ℃; for 0.166667h; Molecular sieve;

methyl α-hydrazonophenylacetate; In dichloromethane; for 2h; diastereoselective reaction;

DOI:10.1021/jo500176g

upstream raw materials:

methyl 2-oxo-2-phenylacetate

Methyl phenyldiazoacetate

Downstream raw materials:

triphenyl<2-((phenyl(methoxycarbonyl)methylene)hydrazono)propyl>phosphonium bromide

6,7-dimethyl-3-methoxy-3-phenyl-1-(2,6-dimethylphenyl)-1H-imidazo<1,2-b>pyrazol-2(3H)-one

triphenyl<2-((phenyl(methoxycarbonyl)methylene)hydrazono)propylidene>phosphorane

triphenyl<1-methyl-2-((phenyl(methoxycarbonyl)methylene)hydrazono)propylidene>phosphorane