1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol

Base Information

• Chemical Name: 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol
• CAS No.: 161664-58-0
• Molecular Formula: C₃₄H₄₈O₆Si
• Molecular Weight: 580.837
• Mol file: 161664-58-0.mol

Synonyms:1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol

Chemical Property of 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol

There total 3 articles about 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2,3,4-tri-O-methyl-1-O-trityl-D-galacitol (151838-14-1) → 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol (161664-58-0)

Guidance literature:

With 1H-imidazole; In dichloromethane;

Reference yield:

2,3,4-tri-O-methyl-D-galacitol (20227-17-2,20227-12-7,20227-24-1,36725-73-2) → 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol (161664-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 percent / DMAP, pyridine / 24 h / Ambient temperature

2: 78 percent / imidazole / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; In dichloromethane;

Reference yield:

2.3.4-Tri-O-methyl-D-galactose (4060-09-7,4060-13-3,4239-83-2,5856-24-6,7330-01-0,40896-77-3,58894-01-2) → 1-O-(tert-butyldimethylsilyl)-3,4,5-tri-O-methyl-6-O-trutyl-L-galacitol (161664-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / NaBH₄ / ethanol

2: 18 percent / DMAP, pyridine / 24 h / Ambient temperature

3: 78 percent / imidazole / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; In ethanol; dichloromethane;

upstream raw materials:

tert-butyldimethylsilyl chloride

2,3,4-tri-O-methyl-1-O-trityl-D-galacitol

2,3,4-tri-O-methyl-D-galacitol

2.3.4-Tri-O-methyl-D-galactose

Downstream raw materials:

2,3,4,5-tetra-O-methyl-6-O-trityl-L-galactose

2,3,4,5-tetra-O-methyl-6-O-trityl-L-galacitol

1-O-(tert-butyldimethylsilyl)-2,3,4,5-tetra-O-methyl-6-O-trityl-L-galacitol