(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

Base Information

Chemical Name:(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate
CAS No.:227619-03-6
Molecular Formula:C₁₅H₁₈ClNO₆
Molecular Weight:343.764
Hs Code.:

Synonyms:(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

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Chemical Property of (S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

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Technology Process of (S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

There total 6 articles about (S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 108-24-7
acetic anhydride

: (S)-3-chloro-β,4,5-trihydroxy-N-methylbenzeneethanamine hydrochloride

: 227619-03-6
(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

Guidance literature:: With sodium hydrogencarbonate; In chloroform; water; for 0.5h;
DOI:10.1007/PL00010225

Reference yield:

: 227618-90-8
(S)-(phenylmethyl) N-(2-(3-chloro-4,5-di(phenylmethoxy)-phenyl)-2-hydroxyethyl)-N-methylcarbamate

: 227619-03-6
(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂, HCl / 10 percent Pd/C / methanol; diethyl ether / 3000.24 Torr

2: 59 percent / NaHCO₃ / H₂O; CHCl₃ / 0.5 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; diethyl ether; chloroform; water;
DOI:10.1007/PL00010225

Reference yield:

: (2S-(2α,3aα,4β,7β,7aα))-3-chloro-α-((octahydro-7,8,8-trimethyl-4,7-methano-benzofuran-2-yl)oxy)-4,5-di(phenylmethoxy)-benzeneacetonitrile

: 227619-03-6
(S)-5-(2-(acetylmethylamino)-1-hydroxyethyl)-3-chloro-1,2-phenylene diacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 38 percent / LiAlH₄ / diethyl ether

2: 97 percent / aq. NaOH / diethyl ether / Ambient temperature

3: 97 percent / LDA / tetrahydrofuran

4: 82 percent / HCl, MeOH / diethyl ether / Ambient temperature

5: 94 percent / H₂, HCl / 10 percent Pd/C / methanol; diethyl ether / 3000.24 Torr

6: 59 percent / NaHCO₃ / H₂O; CHCl₃ / 0.5 h

With hydrogenchloride; methanol; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; chloroform; water;
DOI:10.1007/PL00010225