Technology Process of (E)-(S)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-6-enoic acid methyl ester
There total 7 articles about (E)-(S)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-6-enoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating
2: 71 percent / TiCl4 / CH2Cl2 / 0.5 h
3: DMSO, (COCl)2 / CH2Cl2 / 0.25 h
4: dibenzylammonium trifluoroacetate / benzene / 2 h / 0 - 5 °C
5: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h
6: 74 percent / imidazole / dimethylformamide / 48 h / Ambient temperature
7: 1.) Bu3SnH, azobisisobutyronitrile, 2.) I2 / 1.) 130 deg C, 2 h, 2.) CH2Cl2, 0 deg C
With
1H-imidazole; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; titanium tetrachloride; toluene-4-sulfonic acid; dimethyl sulfoxide; dibenzylammonium trifluoroacetate salt;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0040-4020(96)00316-X
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 74 percent / imidazole / dimethylformamide / 48 h / Ambient temperature
2: 1.) Bu3SnH, azobisisobutyronitrile, 2.) I2 / 1.) 130 deg C, 2 h, 2.) CH2Cl2, 0 deg C
With
1H-imidazole; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride;
In
N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00316-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h
2: 74 percent / imidazole / dimethylformamide / 48 h / Ambient temperature
3: 1.) Bu3SnH, azobisisobutyronitrile, 2.) I2 / 1.) 130 deg C, 2 h, 2.) CH2Cl2, 0 deg C
With
1H-imidazole; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00316-X
