N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide
• CAS No.: 107976-57-8
• Molecular Formula: C₁₇H₁₆N₂O₄S
• Molecular Weight: 344.391
• Mol file: 107976-57-8.mol

Synonyms:N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide

There total 4 articles about N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-bromo-ethyl)-4-methyl-benzenesulfonamide (4556-90-5) + potassium phtalimide (1074-82-4) → N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide (107976-57-8)

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1246/cl.1986.369

Reference yield: 82.0%

phthalic anhydride (85-44-9) + N-tosylethylenediamine (14316-16-6) → N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide (107976-57-8)

Guidance literature:

With sodium acetate; acetic acid; for 24h; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01407

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-4-methylbenzenesulfonamide (107976-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: sodium acetate; acetic acid / 24 h / Reflux; Inert atmosphere

With sodium acetate; acetic acid; triethylamine; In dichloromethane;

DOI:10.1021/acs.orglett.8b01407

upstream raw materials:

N-(2-bromo-ethyl)-4-methyl-benzenesulfonamide

potassium phtalimide

phthalic anhydride

N-tosylethylenediamine

Downstream raw materials:

2-(1,3-dioxoisoindolin-2-yl)ethyl 4-methylbenzenesulfonate

2,3-dihydrophthalazine-1,4-dione

N-(2-Formylamino-ethyl)-4-methyl-benzenesulfonamide

dimethyl amine