2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester
CAS No.:913625-60-2
Molecular Formula:C₃₃H₃₈O₉
Molecular Weight:578.659
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

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Technology Process of 2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

There total 9 articles about 2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865872-73-7
(3S,4S)-4-(4-benzyloxy-3-methoxyphenyl)-3-pivaloyloxymethyl-4-butanolide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 913625-60-2
2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: (3S,4S)-4-(4-benzyloxy-3-methoxyphenyl)-3-pivaloyloxymethyl-4-butanolide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -70 ℃; for 0.25h;

3,4-dimethoxy-benzaldehyde; In tetrahydrofuran; toluene; at -70 ℃; for 1h;
DOI:10.1271/bbb.69.113

Reference yield:

: 868128-07-8
2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-5-hydroxy-tetrahydro-furan-3-ylmethyl ester

: 913625-60-2
2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / pyridinium chlorochrmoate; molecular sieves 4 Angstroem / CH₂Cl₂ / 16 h / 20 °C

2.1: KHMDS / tetrahydrofuran; toluene / 0.25 h / -70 °C

2.2: tetrahydrofuran; toluene / 1 h / -70 °C

With 4 A molecular sieve; potassium hexamethylsilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1271/bbb.69.113

Reference yield:

: 865872-70-4
(2S)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-penten-1-ol

: 913625-60-2
2,2-dimethyl-propionic acid 2-(4-benzyloxy-3-methoxy-phenyl)-4-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

2.1: OsO₄; 4-methylmorpholine N-oxide / H₂O; 2-methyl-propan-2-ol; acetone / 16 h / 20 °C

3.1: 13.6 g / NaIO₄ / methanol / 1 h / 20 °C

4.1: 94 percent / (n-Bu)4NF / tetrahydrofuran / 1 h / 0 °C

5.1: 82 percent / pyridinium chlorochrmoate; molecular sieves 4 Angstroem / CH₂Cl₂ / 16 h / 20 °C

6.1: KHMDS / tetrahydrofuran; toluene / 0.25 h / -70 °C

6.2: tetrahydrofuran; toluene / 1 h / -70 °C

With pyridine; sodium periodate; osmium(VIII) oxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1271/bbb.69.113