3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

Base Information

Chemical Name:3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester
CAS No.:430433-13-9
Molecular Formula:C₃₃H₄₁NO₉
Molecular Weight:595.69
Hs Code.:

Synonyms:3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

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Chemical Property of 3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

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Technology Process of 3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

There total 6 articles about 3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4607-41-4
3-hydroxy-α-oxo-benzenepropanoic acid

: 430433-13-9
3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / hydrogen / Pd/C / ethanol / 3 h / 2585.81 Torr

2.1: 61 percent / p-toluenesulfonic acid monohydrate / dioxane; benzene / 5 h / Heating

3.1: triethylamine / CH₂Cl₂ / -78 - 20 °C

4.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 7.1 g / CH₂Cl₂ / 36 h / 20 °C

With hydrogen; toluene-4-sulfonic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; benzene;
DOI:10.1021/jo011106v

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 430433-13-9
3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / acetic anhydride / 6 h / Heating

2.1: 45 percent / hydrochloric acid / H₂O / 14 h / Heating

3.1: 99 percent / hydrogen / Pd/C / ethanol / 3 h / 2585.81 Torr

4.1: 61 percent / p-toluenesulfonic acid monohydrate / dioxane; benzene / 5 h / Heating

5.1: triethylamine / CH₂Cl₂ / -78 - 20 °C

6.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

6.2: 7.1 g / CH₂Cl₂ / 36 h / 20 °C

With hydrogenchloride; hydrogen; acetic anhydride; toluene-4-sulfonic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; benzene;
DOI:10.1021/jo011106v

Reference yield:

: Acetic acid 3-[2-methyl-5-oxo-oxazol-(4E)-ylidenemethyl]-phenyl ester

: 430433-13-9
3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 45 percent / hydrochloric acid / H₂O / 14 h / Heating

2.1: 99 percent / hydrogen / Pd/C / ethanol / 3 h / 2585.81 Torr

3.1: 61 percent / p-toluenesulfonic acid monohydrate / dioxane; benzene / 5 h / Heating

4.1: triethylamine / CH₂Cl₂ / -78 - 20 °C

5.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

5.2: 7.1 g / CH₂Cl₂ / 36 h / 20 °C

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; benzene;
DOI:10.1021/jo011106v