Benzenepropanoic acid, 3-hydroxy-.alpha.-oxo-

Base Information

• Chemical Name: Benzenepropanoic acid, 3-hydroxy-.alpha.-oxo-
• CAS No.: 4607-41-4
• Molecular Formula: C9H8O4
• Molecular Weight: 180.16
• Hs Code.: 2918990090
• Mol file: 4607-41-4.mol

Synonyms:3-(3-Hydroxyphenyl)-2-oxopropanoic acid;BENZENEPROPANOICACID,3-HYDROXY-.ALPHA.-OXO-;

Chemical Property of Benzenepropanoic acid, 3-hydroxy-.alpha.-oxo-

Chemical Property:

• PSA: 74.60000
• LogP: 0.58840

Purity/Quality:

99.0% ^*data from raw suppliers

3-(3-Hydroxyphenyl)-2-oxopropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: m-Hydroxyphenylpyruvic Acid is a reactant used for the preparation of (±)-thaxtomin A which exhibits different phytotoxic, fungicidal, and antiviral activities.

Technology Process of Benzenepropanoic acid, 3-hydroxy-.alpha.-oxo-

There total 7 articles about Benzenepropanoic acid, 3-hydroxy-.alpha.-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Acetic acid 3-[2-methyl-5-oxo-oxazol-(4E)-ylidenemethyl]-phenyl ester → 3-hydroxy-α-oxo-benzenepropanoic acid (4607-41-4)

Guidance literature:

With hydrogenchloride; In water; for 14h; Heating;

DOI:10.1021/jo011106v

Reference yield: 36.0%

meta-hydroxybenzaldehyde (100-83-4) + N-acetylglycine (543-24-8) → 3-hydroxy-α-oxo-benzenepropanoic acid (4607-41-4)

Guidance literature:

meta-hydroxybenzaldehyde; N-acetylglycine; With sodium acetate; acetic anhydride; at 120 ℃; for 5h;

With hydrogenchloride; In acetic anhydride; at 100 ℃; for 4h;

DOI:10.1039/c4ob01148a

Reference yield:

4-(3-acetoxy-benzylidene)-2-methyl-4H-oxazol-5-one (41888-66-8) → 3-hydroxy-α-oxo-benzenepropanoic acid (4607-41-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo01116a023

upstream raw materials:

4-(3-acetoxy-benzylidene)-2-methyl-4H-oxazol-5-one

4-((Z)-3-acetoxy-benzylidene)-2-phenyl-4H-oxazol-5-one

meta-hydroxybenzaldehyde

N-acetylglycine

Downstream raw materials:

D/L-3-hydroxy-phenylalanine

(±)-thaxtomin A

C₂₂H₂₂N₄O₆

3-(3-Allyloxycarbonyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetoxy)-propionic acid benzyl ester