3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Chemical Name:3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile
CAS No.:1260538-70-2
Molecular Formula:C₂₄H₁₄F₃N₅
Molecular Weight:429.404
Hs Code.:

Synonyms:3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Chemical Property of 3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Technology Process of 3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

There total 5 articles about 3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1260535-36-1
3-{3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl}quinoline

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1260538-70-2
3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 60h;

Reference yield:

: 956010-87-0
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

: 1260538-70-2
3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane; n-heptane / 1 h / 0 - 20 °C

2.1: trichlorophosphate / 1 h / 100 °C

2.2: pH 10 / Cooling with ice

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4.1: 1-methyl-pyrrolidin-2-one / 60 h / 120 °C

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; n-heptane; water; 3.1: Suzuki Coupling;

Reference yield:

: 372-48-5
2-fluoropyridine

: 1260538-70-2
3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: 6 h / 60 °C

2.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane; n-heptane / 1 h / 0 - 20 °C

3.1: trichlorophosphate / 1 h / 100 °C

3.2: pH 10 / Cooling with ice

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

5.1: 1-methyl-pyrrolidin-2-one / 60 h / 120 °C

With n-butyllithium; sodium carbonate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; hexane; n-heptane; water; 4.1: Suzuki Coupling;