956010-87-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine is utilized as a building block for the synthesis of innovative drugs. Its unique chemical structure allows for the development of new therapeutic agents that can potentially address unmet medical needs or improve upon existing treatments.
Used in Agrochemical Industry:
In the agrochemical field, 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine may serve as an active ingredient in the formulation of pesticides. Its specific properties could contribute to the creation of more effective and targeted pest control solutions, enhancing crop protection and yield.

InChI:InChI=1/C7H4F3N3/c8-7(9,10)5-4-2-1-3-11-6(4)13-12-5/h1-3H,(H,11,12,13)

Upstream product

• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 1092459-51-2 1-(2-bromo-3-pyridinyl)-2,2,2-trifluoroethanol 
• 372-48-5 2-fluoropyridine 
• 886371-13-7 C₇H₃BrF₃NO 
• 383-63-1 ethyl trifluoroacetate, 
• 1186608-79-6 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone 

Downstream Products

• 1186608-80-9 5-nitro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 1186608-81-0 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-5-amine 
• 956291-15-9 1-(2,3-Difluorobenzyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956291-09-1 1-(Cycloheptylmethyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956291-13-7 1-(Cyclohexylmethyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956291-11-5 1-(Cyclopentylmethyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956291-23-9 1-(Cyclohexylmethyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 956291-22-8 1-(Cyclopentylmethyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 627076-46-4 1-(2,3-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 956011-21-5 1-(cycloheptylmethyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 1346169-42-3 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956011-27-1 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazol-5(4H)-one 
• 956011-28-2 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-thiadiazol-5(4H)-one 
• 956011-33-9 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazole-5(4H)-thione 

Relevant academic research and scientific papers

Use of 3-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridine as a versatile building block

A one-pot multigram synthesis of 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine starting from 2-fluoropyridine using directed ortho metallation (DoM) technique is described. The compound contains an anionically activatable trifluoromethyl group and is a versatile building block for the microwave assisted synthesis of 3-substituted 1H-pyrazolo[3,4-b]pyridines.

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.

AZABICYCLO COMPOUND AND SALT THEREOF

It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.

1H-PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING RAF KINASE

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I]

Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses

The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof

The present application relates to novel 3-tetrazolylindazole and 3-tetrazolylpyrazolo[3,4-b]-pyridine derivatives, processes for their preparation, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEROF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein X, Y, Z, R1, R2 and R3 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.