4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

Base Information

Chemical Name:4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile
CAS No.:1541988-22-0
Molecular Formula:C₁₅H₁₁ClN₄O
Molecular Weight:298.732
Hs Code.:

Synonyms:4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

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Chemical Property of 4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

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Technology Process of 4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

There total 7 articles about 4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1541988-19-5
4-[(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

: 74-88-4
methyl iodide

: 1541988-22-0
4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

: 1541988-65-1
4-[(5-chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 12h;
DOI:10.1021/jo402599s

Reference yield:

: 767-00-0
4-cyanophenol

: 1541988-22-0
4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

: 1541988-65-1
4-[(5-chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 12 h / 20 °C

2.1: sodium hydroxide; water / methanol / 1 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 50 °C

3.2: 6 h / 50 °C

4.1: acetic acid / 6 h / Reflux; Heating

5.1: potassium carbonate / acetone / 12 h / 20 °C

With water; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo402599s

Reference yield:

: 1878-82-6
(4-cyanophenoxy)acetic acid

: 1541988-22-0
4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

: 1541988-65-1
4-[(5-chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 50 °C

1.2: 6 h / 50 °C

2.1: acetic acid / 6 h / Reflux; Heating

3.1: potassium carbonate / acetone / 12 h / 20 °C

With potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; acetone;
DOI:10.1021/jo402599s