2-(4-chloro-2-aminophenyl)-5-methylfuran

Base Information

• Chemical Name: 2-(4-chloro-2-aminophenyl)-5-methylfuran
• CAS No.: 1045704-67-3
• Molecular Formula: C₁₁H₁₀ClNO
• Molecular Weight: 207.659
• Mol file: 1045704-67-3.mol

Synonyms:2-(4-chloro-2-aminophenyl)-5-methylfuran

Chemical Property of 2-(4-chloro-2-aminophenyl)-5-methylfuran

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chloro-2-aminophenyl)-5-methylfuran

There total 4 articles about 2-(4-chloro-2-aminophenyl)-5-methylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-methyl-5-(4-chloro-2-nitrophenyl)-furan (1045704-63-9) → 2-(4-chloro-2-aminophenyl)-5-methylfuran (1045704-67-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tet.2011.10.114

Reference yield:

5-(4-chloro-2-nitrophenyl)-2-furaldehyde (480439-09-6) → 2-(4-chloro-2-aminophenyl)-5-methylfuran (1045704-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃; NaBH₄ / tetrahydrofuran / Heating

2: hydrazin hydrate / Raney nickel / ethanol / Heating

With sodium tetrahydroborate; aluminium trichloride; hydrazine hydrate; nickel; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tetlet.2006.04.080

Reference yield:

furfural (98-01-1) → 2-(4-chloro-2-aminophenyl)-5-methylfuran (1045704-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCl / H₂O / 0.5 h / 80 °C

1.2: NaNO₂ / H₂O / 0.67 h / -10 - 0 °C

1.3: CuCl₂ / acetone; H₂O / 12 h / 20 °C

2.1: AlCl₃; NaBH₄ / tetrahydrofuran / Heating

3.1: hydrazin hydrate / Raney nickel / ethanol / Heating

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; hydrazine hydrate; nickel; In tetrahydrofuran; ethanol; water; 1.1: Meerwein method;

DOI:10.1016/j.tetlet.2006.04.080

upstream raw materials:

2-methyl-5-(4-chloro-2-nitrophenyl)-furan

furfural

4-Chloro-2-nitroaniline

5-(4-chloro-2-nitrophenyl)-2-furaldehyde

Downstream raw materials:

2-amino-N-[5-chloro-2-(5-methyl-2-furyl)phenyl]acetamide

N-[5-chloro-2-(5-methyl-2-furyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

(3E)-4-[6-chloro-2-(2-nitrophenyl)-1H-indol-3-yl]but-3-en-2-one

(3E)-4-[6-chloro-2-(4,5-dimethoxy-2-nitrophenyl)-1H-indol-3-yl]but-3-en-2-one