480439-09-6

Basic information

• Product Name: 5-(4-CHLORO-2-NITROPHENYL)FURFURAL 97
• Synonyms: 5-(4-CHLORO-2-NITROPHENYL)FURFURAL 97
• CAS NO: 480439-09-6
• Molecular Formula: C₁₁H₆ClNO₄
• Molecular Weight: 251.624
• Product Categories: API intermediates;Building Blocks;Furans;FuransHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 480439-09-6.mol

Chemical Properties

• Melting Point: 91-95 °C(lit.)
• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 197°C
• Appearance: /
• Density: 1.454g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 5-(4-CHLORO-2-NITROPHENYL)FURFURAL 97(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLORO-2-NITROPHENYL)FURFURAL 97(480439-09-6)
• EPA Substance Registry System: 5-(4-CHLORO-2-NITROPHENYL)FURFURAL 97(480439-09-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 480439-09-6(Hazardous Substances Data)

Usage

Properties

1. Chemical formula: C10H5ClNO4
2. Molecular weight: 229.61 g/mol
3. Purity: 97%
4. Intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes
5. Potential applications in organic chemistry as a reagent or building block

Specific content

1. Chlorine and nitro group substituted on the phenyl ring
2. Used as an intermediate in various industries
3. Suitable for research and industrial applications due to 97% purity
4. Molecular formula: C10H5ClNO4

InChI:InChI=1/C11H6ClNO4/c12-7-1-3-9(10(5-7)13(15)16)11-4-2-8(6-14)17-11/h1-6H

Upstream product

• 98-01-1 furfural 
• 89-63-4 4-Chloro-2-nitroaniline 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 

Downstream Products

• 1045704-63-9 2-methyl-5-(4-chloro-2-nitrophenyl)-furan 
• 1045704-67-3 2-(4-chloro-2-aminophenyl)-5-methylfuran 
• 900530-20-3 4-methyl-N-[5-chloro-2-(5-methyl-2-furyl)phenyl]benzenesulfonamide 
• 1032383-40-6 trans-2-[2-[5-(4-chloro-2-nitrophenyl)furan-2-yl]vinyl]-1-methylquinolinium iodide 
• 1287721-80-5 C₂₃H₁₅ClN₄O₄S₂ 
• 1282538-96-8 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(4-chloro-2-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1314797-66-4 C₂₀H₂₀ClNO₉ 
• 1352548-38-9 5-([5-(4-chloro-2-nitrophenyl)-2-furyl]methyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 1352548-40-3 3-[5-(4-chloro-2-nitrophenyl)-2-furyl]propionic acid 
• 1352548-08-3 methyl 3-[5-(4-chloro-2-nitrophenyl)-2-furyl]propionate 
• 1352548-12-9 methyl 3-[5-(4-chloro-2-aminophenyl)-2-furyl]propionate 
• 1352548-19-6 methyl 3-[5-(4-chloro-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate 
• 1352548-26-5 1-(6-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone 
• 1352548-35-6 N-[5-chloro-2-(4-oxopentanoyl)phenyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Synthesis and biological evaluation of 2-phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 inhibitors

In a search for novel molecules to treat inflammatory disorders, we identified several compounds with inhibitory action against the IKK2 enzyme using in silico methods. Based on the virtual hit of compounds 1 and 2, a novel series of 2-phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-one derivatives was designed, synthesized, and evaluated for IKK2 inhibitory activity. Among the synthesized derivatives, compounds 17f and 19f showed good IKK2 inhibitory potency, which have 4-carboxaminophenyl on the 2-furan ring and a methoxy group on the phenylimino moiety at the 2-position of the core structure. The most potent compound was 2-(2,4-dimethoxyphenyl)imino-5((5(4-carboxaminophenyl)furan-2-yl)methylene)thiazolidin-4-one (19f, IC50 = 0.94 μM), which represents a synergic effect of the two virtual hit compounds against IKK2. We also identified compounds showing inhibitory activities against interleukin (IL)-17, CCK-8, and tumor necrosis factor-alpha (TNF-α), which are NF-κB-dependent pro-inflammatory cytokine mediators.

Palladium-catalyzed decarboxylative C-H bond arylation of furans

A Pd/PCy3/Ag2CO3 (Cy = cyclohexyl) catalytic system was found to promote decarboxylative arylation through the combination of decarboxylation and C-H bond functionalization. This protocol features a good substrate scope of

A new simple route to the thieno[2,3-b]indole ring system

A simple and effective method has been elaborated for the synthesis of thieno[2,3-b]indole ring system. It is based on the electrophilic recyclization of 2-alkyl-5-(2-isothiocyanoaryl)furans in the presence of anhydrous AlCl 3. Georg Thieme Ver

Furan as a 1,3-diketone equivalent: the second type furan recyclization applied to indole synthesis

A new approach for the synthesis of indole derivatives based on protolytic recyclization of 2-alkyl-5-(2-tosylaminoaryl)-furans is described. The furan ring in this unusual transformation formally serves as a 1,3-diketone equivalent.