(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Base Information

Chemical Name:(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid
CAS No.:1439368-16-7
Molecular Formula:C₁₆H₁₇NO₅S
Molecular Weight:335.381
Hs Code.:

Synonyms:(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Suppliers and Price of (2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

There total 2 articles about (2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1659-31-0
2,2'-dipyridyl carbonate

: 632-20-2,134357-96-3,7013-32-3,82822-12-6
D-Threonine

: 160278-20-6
3-(4-hydroxymethyl-phenyl)thiophene

: 1439368-16-7
(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Guidance literature:: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene; With dmap; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

D-Threonine; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 15h;
DOI:10.1021/jm501455s

Reference yield:

: 29886-64-4
4-(thiophen-3-yl)benzoic acid

: 1439368-16-7
(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

Reference yield: 27.0%

: 1439368-16-7
(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

: 1439366-96-7
[4-(3-thienyl)-phenyl]-methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm501455s