(4-(Thiophen-3-yl)phenyl)methanol

Base Information

• Chemical Name: (4-(Thiophen-3-yl)phenyl)methanol
• CAS No.: 160278-20-6
• Molecular Formula: C11H10 O S
• Molecular Weight: 190.266
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20569821
• Wikidata: Q82457056
• Mol file: 160278-20-6.mol

Synonyms:160278-20-6;(4-(Thiophen-3-yl)phenyl)methanol;[4-(thiophen-3-yl)phenyl]methanol;(4-Thien-3-ylphenyl)methanol;(4-thiophen-3-ylphenyl)methanol;Benzenemethanol, 4-(3-thienyl)-;[4-(3-Thienyl)phenyl]methanol;Methylbeta-D-ribofuranoside;4-Thien-3-yl-benzyl alcohol;SCHEMBL8309627;Benzenemethanol,4-(3-thienyl)-;DTXSID20569821;KEHJEXSFOWCTHM-UHFFFAOYSA-N;(4-Thiophen-3-yl-phenyl)methanol;[4-(3-thienyl)-phenyl]-methanol;AMY32429;MFCD06203084;AKOS004118666;MS-22432;EN300-179685;F18374;Z1201623386

Chemical Property of (4-(Thiophen-3-yl)phenyl)methanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 151.5-154oC
• Boiling Point: 311.849oC at 760 mmHg
• PKA: 14.37±0.10(Predicted)
• Flash Point: 142.402oC
• PSA: 48.47000
• Density: 1.204g/cm3
• LogP: 2.90740
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.04523611
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

(4-Thien-3-ylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CO)C2=CSC=C2

Technology Process of (4-(Thiophen-3-yl)phenyl)methanol

There total 8 articles about (4-(Thiophen-3-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyldimethyl[(4-thien-3-ylbenzyl)oxy]silane (160278-19-3) → 3-(4-hydroxymethyl-phenyl)thiophene (160278-20-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 0.75h;

DOI:10.1021/ma011227x

Reference yield: 88.5%

4-(3-thienyl)benzyl acetate (164399-47-7) → 3-(4-hydroxymethyl-phenyl)thiophene (160278-20-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Heating;

Reference yield: 65.0%

4-(thiophen-3-yl)benzoic acid (29886-64-4) → 3-(4-hydroxymethyl-phenyl)thiophene (160278-20-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

4-(3-thienyl)benzyl acetate

4-bromobenzenemethanol

tri-n-butyl(thien-3-yl)tin

tert-butyldimethyl[(4-thien-3-ylbenzyl)oxy]silane

Downstream raw materials:

2,3-epoxy-4-(3-thienyl)-benzyloxypropane

3-(4-bromomethyl-phenyl)thiophene

1-(4-[Thien-3-yl]phenylmethyl)-5-(4-cyanobenzyl)imidazole hydrochloride salt

[4-(3-thienyl)-phenyl]-methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate