5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Base Information

Chemical Name:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride
CAS No.:1184298-52-9
Molecular Formula:C₂₃H₂₇ClFN₅O₅S₂*ClH
Molecular Weight:608.542
Hs Code.:

5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Synonyms:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Suppliers and Price of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

There total 11 articles about 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1184298-56-3
2-fluoro-3-(2-oxo-pyrrolidinyl)-benzenesulfonyl chloride

: 5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide dihydrochloride

: 1184298-52-9
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1184298-52-9
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: disodium hydrogenphosphate / chloroform / 20 °C

2: ethanol; sodium / 20 °C

3: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

4: sulfuryl dichloride; water; acetic acid / dichloromethane / 0.42 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 °C

With disodium hydrogenphosphate; sulfuryl dichloride; ethanol; water; sodium; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; chloroform;

Reference yield:

: 1184298-54-1
1-(3-bromo-2-fluoro-phenyl)-pyrrolidin-2-one

: 1184298-52-9
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-fluoro-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

2: sulfuryl dichloride; water; acetic acid / dichloromethane / 0.42 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0 °C

With sulfuryl dichloride; water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;