2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole

Base Information

• Chemical Name: 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole
• CAS No.: 174153-42-5
• Molecular Formula: C₂₃H₂₈N₂O₂Si
• Molecular Weight: 392.573
• Mol file: 174153-42-5.mol

Synonyms:2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole

Chemical Property of 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole

There total 1 articles about 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,2-diphenyl-1,4-pentanedione (25234-76-8) + 1-hydrazinecarboxylic acid 2-(trimethylsilyl)ethyl ester (154876-20-7) → 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole (174153-42-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In toluene; at 50 ℃; for 10h;

DOI:10.1021/jo9518260

Reference yield: 71.0%

2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole (174153-42-5) → 1-amino-2,3-diphenyl-5-methylpyrrole (56138-40-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jo9518260

Reference yield:

2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole (174153-42-5) → 1-(2,3-diphenyl-5-methylpyrrolyl)-2-(2-furanyl)-5-methyl-3-phenylpyrrole

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / nBu₄NF / tetrahydrofuran / 5 h / Ambient temperature

2: 82 percent / p-toluenesulfonic acid / toluene / 90 °C

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jo9518260

upstream raw materials:

1,2-diphenyl-1,4-pentanedione

1-hydrazinecarboxylic acid 2-(trimethylsilyl)ethyl ester

Downstream raw materials:

1-amino-2,3-diphenyl-5-methylpyrrole