25234-76-8

Upstream product

• 591-51-5 phenyllithium 
• 1896-62-4 (E)-benzalacetone 
• 937-53-1 (Z)-4-phenylbut-3-en-2-one 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 38720-22-8 (2-methyl-4-phenyl-1-oxabuta-1,3-diene)tricarbonyliron⁽⁰⁾ 
• 100-52-7 benzaldehyde 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 451-40-1 phenyl benzyl ketone 
• 56346-03-3 C₁₁H₁₄LiNOSi 
• 27702-63-2 3-diethylamino-1,2-diphenyl-propan-1-one 
• 38940-37-3 1,2-diphenylpent-4-yn-1-one 
• 73593-46-1 5-Oxo-2,3-diphenyl-2-(trimethylsiloxy)hexannitril 
• 83188-06-1 4-Nitro-1,2-diphenyl-pentan-1-one 

Downstream Products

• 174153-42-5 2,3-diphenyl-5-methyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole 
• 56138-40-0 1-amino-2,3-diphenyl-5-methylpyrrole 
• 59214-47-0 ethyl 2-(5-methyl-2,3-diphenyl-1H-pyrrol-1-yl)acetate 
• 1312717-37-5 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid 
• 1312717-95-5 ethyl 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate 

Relevant academic research and scientific papers

Neutral-eosin Y-catalyzed regioselective hydroacylation of aryl alkenes under visible-light irradiation

Styrene derivatives were hydroacylated with exclusive anti-Markovnikov selectivity by using neutral eosin Y as a direct hydrogen-atom-transfer (HAT) catalyst under visible-light irradiation. Aldehydes and styrenes with various substituents were tolerated (>20 examples), giving the corresponding products in moderate to high yields. The key acyl radical intermediate was generated from a direct HAT process induced by photoexcited eosin Y. Subsequent addition to styrenes and a reverse HAT process generated the ketone products.

Thulium Triflate Catalyzed Hydration of 2-Substituted 4-Alkynones

We report on a facile synthetic route for the preparation of substituted 1,4-diketones by thulium triflate mediated hydration of substituted 4-alkynones in MeNO2 at 25 °C for five hours. The products were obtained in moderate to high yields.

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:

Nucleophilic Addition to Tricarbonyliron Complexes of α,β-Unsaturated Ketones and the Production of 1,4-Diketones

The first examples of nucleophilic addition to tricarbonyliron complexes α,β-unsaturated ketones are described.Addition of Grignard, organolithium, and organocuprate reagents to the tricarbonyliron complex of benzylideneacetone (1) gives 1,4-diketones.The synthesis and reactivity of the tricarbonyliron complexes of PhCH=CHCOR, R=Bu (7), R=Bui (8), and R=But (9) are reported.

One-Step Synthesis of 1,4-Diketones by Nucleophilic Reaction to Tricarbonyl Complexes of α,β-Unsaturated Ketones

Tricarbonyliron complexes of 3-buten-2-one, 3-penten-2-one, and 4-phenyl-3-buten-2-one reacted with organolithium and Grignard reagents to afford 1,4-diketones in one step, some of the products are amenable to convertion to natural products.

(Phosphine)carbonylnitrosylacylcobaltate Complexes as Acyl Transfer Reagents. Acylation of Allylic Halides, Conjugated Enones, and Quinones

The complex Co(NO)(CO)2(PPh3) is an air stable, easily handled crystalline solid, prepared from Co2(CO)8, sodium nitrite, and triphenylphosphine without isolation of the volatile intermediate Co(NO)(CO)3.Treatment of this complex with organolithium reagents at -40 deg C generated unstable acylate complexes - which readily transferred the acyl group to allylic halides to produce β,γ-unsaturated ketones, to conjugated ketones to produce 1,4-dicarbonyl compounds, and to quinones to form 4-acylcyclohexadienones.

The Synthesis of 1,4-Diketones via Fluoride-catalysed Michael Addition and Supported-permanganate-promoted Nef Transformation

A versatile synthetic route for the preparation of 1,4-diketones from simple starting materials is described and applied to the preparation of a wide range of diketones.The two most important steps in the reaction are the fluoride ion-catalysed Michael addition of a nitroalkane to a vinyl ketone and the subsequent transformation of the nitro ketone to the diketone using supported permanganate as the oxidant.The interaction of F- with nitroethane has been studied and a number of sources of F- have been tested in the Michael addition reaction.Potassium fluoride supported on alumina and potassium permanganate supported on silica gel are remarkably efficient reagents for the Michael addition and Nef transformation stages, respectively, although it is important to determine the best reagent loadings and drying conditions for maximum reaction efficiency to be achieved.

Synthesis of 1,4-Diketones by Fluoride-catalysed Michael Addition and Supported Permanganate Oxidation

A wide variety of 1,4-diketones may be prepared from simple starting materials by using fluoride ion-catalysed Michael additions and silica gel-supported permanganate-promoted Nef transformations.

Trimethylsilyl Cyanide - A Reagent for Umpolung, III: Nucleophilic Acylation of α,β-Unsaturated Carbonyl Compounds with directed 1,2-/1,4-Additions by Solvent Effects

The anion 7 of O-(trimethylsilyl)cyanohydrine 6, derived from benzaldehyde, attacks numerous α-enones in ether exclusively by 1,4-addition, even if C-3 is alkyl-substituted.In THF and DME the 1,2-adduct is formed predominantly; on addition of HMPT or 12-c

Process for preparing ketones

Ketones are prepared by reacting an aromatic or heterocyclic aldehyde in the presence of a cyanide ion with an unsaturated compound having the formula (I): STR1 wherein R1, R2 and R3 are the same or different and are selected from the group of hydrogen, optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic, heterocyclic and carboxylic acid ester and R4 is nitrile (CN), --CO--R5 or --CO--OR5 wherein R5 is selected from the group of optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic and heterocyclic and R1 and R2 and/or R1 and R3 and/or R2 and R5 or R3 and R5 together with the carbon atoms to which they are attached as substituents may also form a carbocyclic or heterocyclic ring. Ketones prepared according to the process of the invention have the formula: STR2 wherein R1 ' and R3 ' are identical or different and are selected from the group of hydrogen, lower alkyl having up to 3 C-atoms and optionally substituted phenyl; and R6 ' is optionally substituted phenyl or a pyridyl.