ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

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Chemical Name:ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate
CAS No.:254428-01-8
Molecular Formula:C₂₄H₃₁NO₂
Molecular Weight:365.516
Hs Code.:

Synonyms:ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

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Chemical Property of ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

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Technology Process of ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

There total 2 articles about ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 100-39-0
benzyl bromide

: 254427-95-7
ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate

: 254428-01-8
ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

Guidance literature:: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;
DOI:10.1039/b712503h

Reference yield: 76.0%

: 254427-95-7
ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate

: 254428-01-8
ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate

Guidance literature:: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

CH₂C₆H₅-X, X = halide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(99)01917-6