2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

Base Information

Chemical Name:2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide
CAS No.:1314881-39-4
Molecular Formula:C₂₃H₁₈N₆O₂
Molecular Weight:410.435
Hs Code.:

Synonyms:2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

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Chemical Property of 2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

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Technology Process of 2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

There total 3 articles about 2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1314881-71-4
2-(4-(1-amino-2,4-dicyanobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)phenoxy)acetic acid

: 75-04-7,85404-22-4
ethylamine

: 1314881-39-4
2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

Guidance literature:: 2-(4-(1-amino-2,4-dicyanobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)phenoxy)acetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

ethylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 59031-34-4
2-(4-(2,2-dicyanovinyl)phenoxy)acetic acid

: 1314881-39-4
2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 3 h / Reflux

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With piperidine; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 22042-71-3
(4-formylphenoxy)acetic acid

: 1314881-39-4
2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]-N-ethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-amino propanoic acid / ethanol / 20 °C

2.1: piperidine / ethanol / 3 h / Reflux

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With piperidine; 1,1'-carbonyldiimidazole; 3-amino propanoic acid; In ethanol; N,N-dimethyl-formamide; 1.1: Knoevenagel condensation;
DOI:10.1016/j.bmc.2011.05.013