Technology Process of 4-hydroxybutyl 2-(2-bromophenyl)-2-diazoacetate
There total 3 articles about 4-hydroxybutyl 2-(2-bromophenyl)-2-diazoacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 20h;
Schlenk technique;
Inert atmosphere;
DOI:10.1055/s-0033-1341062
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium iodide; tetrabutyl phosphonium bromide / N,N-dimethyl-formamide / 17 h / 120 °C / Schlenk technique; Inert atmosphere
2: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Schlenk technique; Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / Schlenk technique; Inert atmosphere
With
4-toluenesulfonyl azide; tetrabutyl ammonium fluoride; tetrabutyl phosphonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-0033-1341062
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Schlenk technique; Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / Schlenk technique; Inert atmosphere
With
4-toluenesulfonyl azide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0033-1341062
