4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate

Base Information

• Chemical Name: 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate
• CAS No.: 1632260-37-7
• Molecular Formula: C₁₈H₂₉BrO₃Si
• Molecular Weight: 401.416
• Mol file: 1632260-37-7.mol

Synonyms:4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate

Chemical Property of 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate

There total 1 articles about 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

potassium 2-bromophenylacetate (63071-77-2) + 4-(t-butyldimethylsiloxy)-1-chlorobutane (89031-83-4) → 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate (1632260-37-7)

Guidance literature:

With tetrabutyl phosphonium bromide; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 17h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1341062

Reference yield:

4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate (1632260-37-7) → 4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)-2-diazoacetate (1632260-42-4)

Guidance literature:

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1341062

Reference yield:

4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)acetate (1632260-37-7) → 4-hydroxybutyl 2-(2-bromophenyl)-2-diazoacetate (1632260-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Schlenk technique; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / Schlenk technique; Inert atmosphere

With 4-toluenesulfonyl azide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; acetonitrile;

DOI:10.1055/s-0033-1341062

upstream raw materials:

potassium 2-bromophenylacetate

4-(t-butyldimethylsiloxy)-1-chlorobutane

Downstream raw materials:

4-hydroxybutyl 2-(2-bromophenyl)-2-diazoacetate

4-(tert-butyldimethylsilyloxy)butyl 2-(2-bromophenyl)-2-diazoacetate