BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Base Information

Chemical Name:BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃
CAS No.:174464-43-8
Molecular Formula:C₃₁H₄₉N₃O₇S₃
Molecular Weight:671.944
Hs Code.:

BOC-Met-An<sup>p</sup>Glu ethylene dithioketal Ile-OCH<sub>3</sub>

Synonyms:BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Suppliers and Price of BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

There total 7 articles about BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-5-(4-methoxy-phenyl)-5-oxo-pentanoic acid tert-butyl ester

: 174464-43-8
BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / triflic acid / CH₂Cl₂ / 1 h / Ambient temperature

2: 49 percent / BF₃*Et₂O / 1) 0 deg C, 15 min; 2) rt, 2 h

3: 90 percent / HCl / ethyl acetate; CH₂Cl₂ / 16 h / Ambient temperature

4: 92 percent / Et₃N / tetrahydrofuran; H₂O / 17 h / Ambient temperature

5: 1.) carbonylbis(3-methylimidazolium triflate), 2.) N-methylmorpholine / 1) THF, MeNO₂, 5 min; 2) THF, MeNO₂, rt, 2 h

6: 93 percent / HCl / ethyl acetate / 3 h / Ambient temperature

7: 1.) methyl triflate, CDI, N-methylimidazole, 2.) N-methylmorpholine / 1) THF, MeNO₂, 0 deg C, 8 min; 2) THF, DMF, rt, 3 h

With 4-methyl-morpholine; 1-methyl-1H-imidazole; hydrogenchloride; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; 1,1'-carbonylbis(3-methyl-1H-imidazol-3-ium) triflate; triethylamine; 1,1'-carbonyldiimidazole; methyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo951754c

Reference yield:

: 174464-37-0
(S)-2-((tert-butoxycarbonyl)amino)-5-<2,2-(1,3-dithiolanyl)>-5-(4-methoxyphenyl)pentanoic acid

: 174464-43-8
BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) carbonylbis(3-methylimidazolium triflate), 2.) N-methylmorpholine / 1) THF, MeNO₂, 5 min; 2) THF, MeNO₂, rt, 2 h

2: 93 percent / HCl / ethyl acetate / 3 h / Ambient temperature

3: 1.) methyl triflate, CDI, N-methylimidazole, 2.) N-methylmorpholine / 1) THF, MeNO₂, 0 deg C, 8 min; 2) THF, DMF, rt, 3 h

With 4-methyl-morpholine; 1-methyl-1H-imidazole; hydrogenchloride; 1,1'-carbonylbis(3-methyl-1H-imidazol-3-ium) triflate; 1,1'-carbonyldiimidazole; methyl trifluoromethanesulfonate; In ethyl acetate;
DOI:10.1021/jo951754c

Reference yield:

: 174464-32-5
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-5-<2,2-(1,3-dithiolanyl)>-5-(4-methoxyphenyl)pentanoate

: 174464-43-8
BOC-Met-An^pGlu ethylene dithioketal Ile-OCH₃

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / HCl / ethyl acetate; CH₂Cl₂ / 16 h / Ambient temperature

2: 92 percent / Et₃N / tetrahydrofuran; H₂O / 17 h / Ambient temperature

3: 1.) carbonylbis(3-methylimidazolium triflate), 2.) N-methylmorpholine / 1) THF, MeNO₂, 5 min; 2) THF, MeNO₂, rt, 2 h

4: 93 percent / HCl / ethyl acetate / 3 h / Ambient temperature

5: 1.) methyl triflate, CDI, N-methylimidazole, 2.) N-methylmorpholine / 1) THF, MeNO₂, 0 deg C, 8 min; 2) THF, DMF, rt, 3 h

With 4-methyl-morpholine; 1-methyl-1H-imidazole; hydrogenchloride; 1,1'-carbonylbis(3-methyl-1H-imidazol-3-ium) triflate; triethylamine; 1,1'-carbonyldiimidazole; methyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo951754c