1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole

Base Information

• Chemical Name: 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole
• CAS No.: 1315307-47-1
• Molecular Formula: C₁₆H₁₆F₃N₃O₂
• Molecular Weight: 339.317
• Mol file: 1315307-47-1.mol

Synonyms:1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole

Chemical Property of 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole

There total 4 articles about 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentanecarbaldoxime hydrochloride (1330124-99-6) + C10H8ClF3N2O2*ClH (1330125-14-8) → 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole (1315307-47-1)

Guidance literature:

With triethylamine; In toluene; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.05.003

Reference yield:

p-trifluoromethylphenylchlorohydrazone (1315307-30-2) + cyclopentanecarbaldehyde oxime (70341-45-6) → 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole (1315307-47-1)

Guidance literature:

With triethylamine; In toluene; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2011.07.009

Reference yield:

cyclopentanealdehyde (872-53-7) → 1-(4-trifluoromethylphenyl)-3-methoxycarbonyl-5-cyclopentyl-1,2,4-triazole (1315307-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / toluene / 20 °C / Inert atmosphere

2: triethylamine / toluene / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; triethylamine; In toluene;

DOI:10.1016/j.tet.2011.05.003

upstream raw materials:

cyclopentanecarbaldoxime hydrochloride

C₁₀H₈ClF₃N₂O₂*ClH

cyclopentanealdehyde

4-trifluoromethylphenylamine