ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Base Information

Chemical Name:ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate
CAS No.:365998-33-0
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Suppliers and Price of ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

There total 11 articles about ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 480449-84-1
ethyl (1S,3R,4S)-4-amino-3-[(tert-butoxycarbonyl)amino]-cyclohexanecarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 365998-33-0
ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20 ℃; for 96h;

Reference yield:

: 1093351-24-6
ethyl (1S,3R,4S)-4-amino-3-t-butoxycarbonylaminocyclohexanecarboxylate oxalate

: 501-53-1,94274-21-2
benzyl chloroformate

: 365998-33-0
ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20 ℃; for 3h;

Reference yield:

: 67976-82-3
(1S)-3-cyclohexene-1-carboxylic acid (R)-(+)-α-methylbenzylamine salt

: 365998-33-0
ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride / ethyl acetate; water / 1.5 h / 55 °C

2: sodium hydrogencarbonate; iodine; potassium iodide / water / 5 h / 20 °C

3: sodium hydroxide / water

4: ammonium hydroxide / water; ethanol / 45 °C

5: ammonium hydroxide / ethanol / 20 °C / Cooling with ice

6: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

7: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 48 h / 75 °C

8: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C

9: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

With hydrogenchloride; ammonium hydroxide; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; iodine; sodium hydrogencarbonate; triethylamine; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2017.01.021