(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Base Information

Chemical Name:(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester
CAS No.:1255529-53-3
Molecular Formula:C₂₂H₃₃N₃O₅
Molecular Weight:419.521
Hs Code.:

Synonyms:(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Suppliers and Price of (1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

There total 13 articles about (1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (1R,3R,4S)-4-(((benzyloxy)carbonyl)amino)-3-((tertbutoxycarbonyl)amino)cyclohexane-1-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1255529-53-3
(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.tet.2017.01.021

Reference yield:

: 4771-80-6
1,2,5,6-tetrahydrobenzoic acid

: 1255529-53-3
(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: acetone / 1.5 h / 55 °C

2: hydrogenchloride / ethyl acetate; water / 1.5 h / 55 °C

3: sodium hydrogencarbonate; iodine; potassium iodide / water / 5 h / 20 °C

4: sodium hydroxide / water

5: ammonium hydroxide / water; ethanol / 45 °C

6: ammonium hydroxide / ethanol / 20 °C / Cooling with ice

7: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

8: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 48 h / 75 °C

9: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C

10: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

11: sodium ethanolate; water / ethanol / 15 h / 20 - 45 °C / Inert atmosphere

12: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; ammonium hydroxide; sodium azide; 15-crown-5; palladium 10% on activated carbon; water; hydrogen; iodine; sodium ethanolate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2017.01.021

Reference yield:

: 123536-66-3
(1S,4S,5S)-4-iodo-6-oxabicyclo<3.2.1>octan-7-one

: 1255529-53-3
(1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / water

2: ammonium hydroxide / water; ethanol / 45 °C

3: ammonium hydroxide / ethanol / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

5: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 48 h / 75 °C

6: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C

7: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

8: sodium ethanolate; water / ethanol / 15 h / 20 - 45 °C / Inert atmosphere

9: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Inert atmosphere

With ammonium hydroxide; sodium azide; 15-crown-5; palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2017.01.021