N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

Base Information

Chemical Name:N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide
CAS No.:1027655-74-8
Molecular Formula:C₂₉H₃₄N₂O₃
Molecular Weight:458.601
Hs Code.:

Synonyms:N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

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Technology Process of N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

There total 5 articles about N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (E)-N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-benzyloxy-phenyl)-acrylamide

: 1027655-74-8
N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm960305h

Reference yield:

: 32669-06-0
1,1'-[(2-chloroethoxy)methylene]bis-benzene

: 1027655-74-8
N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / K₂CO₃ / toluene / 24 h / Heating

2: 93 percent / LiAlH₄ / tetrahydrofuran

3: 1.) DCC, 2.) pyridine / 1.) CH₂Cl₂, 40 min, 2.) CH₂Cl₂, 5 h

4: 93 percent / H₂ / 5percent Pd-C / methanol / 24 h / 760 Torr / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm960305h

Reference yield:

: 91-01-0
1,1-Diphenylmethanol

: 1027655-74-8
N-[(S)-1-(2-Benzhydryloxy-ethyl)-pyrrolidin-2-ylmethyl]-3-(3-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂SO₄ / toluene

2: 36 percent / K₂CO₃ / toluene / 24 h / Heating

3: 93 percent / LiAlH₄ / tetrahydrofuran

4: 1.) DCC, 2.) pyridine / 1.) CH₂Cl₂, 40 min, 2.) CH₂Cl₂, 5 h

5: 93 percent / H₂ / 5percent Pd-C / methanol / 24 h / 760 Torr / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sulfuric acid; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm960305h