((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
CAS No.:110205-86-2
Molecular Formula:C₃₁H₅₁N₃O₈S
Molecular Weight:625.827
Hs Code.:

((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Synonyms:((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of ((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Technology Process of ((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 8 articles about ((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110205-88-4
((S)-1-{(1S,2R)-2-Benzyloxy-1-[(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 110205-86-2
((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00394a035

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 110205-86-2
((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole monohydrate (HOBt), N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / -23 - 20 °C

2: H₂ / 10percent Pd/C / ethyl acetate

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a035

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 110205-86-2
((S)-1-{(1S,2R)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 59 percent / triethylamine / methanol / 2 h / Heating

2: 97 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h

3: HCl / ethanol / Ambient temperature

4: 1-hydroxybenzotriazole monohydrate (HOBt), N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / -23 - 20 °C

5: HCl / ethanol / Ambient temperature

6: 1-hydroxybenzotriazole monohydrate (HOBt), N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / -23 - 20 °C

7: H₂ / 10percent Pd/C / ethyl acetate

With 4-methyl-morpholine; hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a035