(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

Base Information

Chemical Name:(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane
CAS No.:110206-09-2
Molecular Formula:C₁₈H₃₅NO₅S
Molecular Weight:377.546
Hs Code.:

Synonyms:(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

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Chemical Property of (2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

There total 2 articles about (2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 110206-07-0
(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-2-hydroxy-1-(isopropylthio)butane

: 110206-09-2
(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1h;
DOI:10.1021/jm00394a035

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 110206-09-2
(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / triethylamine / methanol / 2 h / Heating

2: 97 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00394a035

Reference yield:

: 110206-09-2
(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

: 110205-92-0
((S)-1-{(S)-5-Amino-1-[(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / ethanol / Ambient temperature

2: 1-hydroxybenzotriazole monohydrate (HOBt), N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / -23 - 20 °C

3: HCl / ethanol / Ambient temperature

4: 1-hydroxybenzotriazole monohydrate (HOBt), N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / -23 - 20 °C

5: H₂ / 10percent Pd/C / ethanol; acetic acid / 760 Torr

With 4-methyl-morpholine; hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a035