ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

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Chemical Name:ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate
CAS No.:1632161-84-2
Molecular Formula:C₃₆H₄₅N₃O₉
Molecular Weight:663.768
Hs Code.:

Synonyms:ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

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Chemical Property of ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

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Technology Process of ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

There total 4 articles about ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1632161-81-9
ethyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-[(2-chloroacetyl)amino]-2-naphthyl]oxy]butanoate

: 593-51-1
methylamine hydrochloride

: 1632161-84-2
ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1039/c4md00032c

Reference yield:

: 1632161-79-5
ethyl 4-[[6-amino-7-(4-benzyloxy-4-oxo-butoxy)-2-naphthyl]oxy]butanoate

: 1632161-84-2
ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

1.2: 2 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4md00032c

Reference yield:

: 582-17-2
2,7-Dihydroxynaphthalene

: 1632161-84-2
ethyl 4-[2-[[3,6-bis(4-ethoxy-4-oxo-butoxy)-2-naphthyl]amino]-2-oxo-ethyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / acetic acid / 1.5 h

1.2: 24 h / 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C

3.1: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; Benzophenone imine / 1,4-dioxane / 15 h / 110 °C / Schlenk technique; Inert atmosphere

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.2: 2 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C

With Benzophenone imine; bromine; palladium diacetate; potassium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4md00032c