1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Base Information

Chemical Name:1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
CAS No.:1034616-36-8
Molecular Formula:C₂₅H₂₉F₃N₈O₂
Molecular Weight:530.553
Hs Code.:

1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Synonyms:1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

There total 4 articles about 1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1034614-87-3
8-{[5-bromo-2-(trifluoromethoxy)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

: 51387-90-7,422545-96-8
2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE

: 1034616-36-8
1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; DavePhos; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.09.060

Reference yield:

: 802537-20-8
8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

: 1034616-36-8
1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 80 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; DavePhos / tetrahydrofuran / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium hexamethyldisilazane; DavePhos; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Buchwald-Hartwig reaction / 2: Buchwald-Hartwig reaction;
DOI:10.1016/j.bmcl.2011.03.054

Reference yield:

: 886762-08-9
5-bromo-2-(trifluoromethoxy)aniline

: 1034616-36-8
1-methyl-8-{[5-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 80 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; DavePhos / tetrahydrofuran / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium hexamethyldisilazane; DavePhos; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Buchwald-Hartwig reaction / 2: Buchwald-Hartwig reaction;
DOI:10.1016/j.bmcl.2011.03.054