1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate
CAS No.:645379-02-8
Molecular Formula:C₂₃H₃₀F₂N₂O₄
Molecular Weight:436.499
Hs Code.:

Synonyms:1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate

There total 1 articles about 1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 645378-45-6
4-(2-cyano-2-ethoxycarbonyl-vinyl)-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

: 452-63-1
2-Bromo-5-fluorotoluene

: 645379-02-8
1,1-dimethylethyl-4-[2-cyano-3-(ethyloxy)-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate

Guidance literature:: 2-Bromo-5-fluorotoluene; With iodine; magnesium; In diethyl ether; for 0.5h; Heating / reflux;

4-(2-cyano-2-ethoxycarbonyl-vinyl)-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester; In diethyl ether; at 20 ℃; for 2h;