N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine

Base Information

• Chemical Name: N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine
• CAS No.: 1187644-22-9
• Molecular Formula: C₄₁H₅₂N₆O₁₀SSi
• Molecular Weight: 849.05

Synonyms:N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine

Chemical Property of N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine

Chemical Property:

Purity/Quality:

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Technology Process of N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine

There total 3 articles about N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide (81256-89-5) → N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine (1187644-22-9)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; sulphamoyl chloride; In chloroform; for 19h;

Reference yield:

G (118-00-3) → N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine (1187644-22-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C / Inert atmosphere

1.2: 3.33 h / 0 - 20 °C

1.3: 0.25 h / 0 - 20 °C

2.1: pyridine / 5 h / 20 °C

3.1: 1H-imidazole / dichloromethane; toluene / Inert atmosphere

4.1: 2,6-di-tert-butyl-4-methylpyridine; sulphamoyl chloride / chloroform / 19 h

With pyridine; 1H-imidazole; chloro-trimethyl-silane; 2,6-di-tert-butyl-4-methylpyridine; sulphamoyl chloride; In dichloromethane; chloroform; toluene;

Reference yield:

N2-isobutyryl-2'-deoxyguanosine (64350-24-9) → N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tertbutyldimethylsilyl-2'-sulfamoyl-guanosine (1187644-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 5 h / 20 °C

2: 1H-imidazole / dichloromethane; toluene / Inert atmosphere

3: 2,6-di-tert-butyl-4-methylpyridine; sulphamoyl chloride / chloroform / 19 h

With pyridine; 1H-imidazole; 2,6-di-tert-butyl-4-methylpyridine; sulphamoyl chloride; In dichloromethane; chloroform; toluene;

upstream raw materials:

G

N²-isobutyryl-2'-deoxyguanosine

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

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