N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

Base Information

Chemical Name:N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine
CAS No.:81256-89-5
Molecular Formula:C₄₁H₅₁N₅O₈Si
Molecular Weight:769.97
Hs Code.:
Mol file:81256-89-5.mol

Synonyms:N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Suppliers and Price of N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
500 mg
$ 185.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
250 mg
$ 95.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
1 g
$ 350.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
5 g
$ 1250.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
2 g
$ 580.00

AK Scientific
5'-DMT-3'-TBDMS-ibu-rG
1g
$ 522.00

AK Scientific
5'-DMT-3'-TBDMS-ibu-rG
500mg
$ 299.00

Total 8 raw suppliers

Chemical Property of N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

Chemical Property:

PKA:9.16±0.20(Predicted)
Density:1.25±0.1 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

There total 4 articles about N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 81246-83-5
9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 81279-39-2
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

: 81256-89-5
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2010.04.064

Reference yield: 24.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 81246-83-5
9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 81256-89-5
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 64350-24-9
N²-isobutyryl-2'-deoxyguanosine

: 81256-89-5
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 25 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 25 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;