(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

Base Information

Chemical Name:(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one
CAS No.:1289116-77-3
Molecular Formula:C₂₉H₂₃N₃O₃
Molecular Weight:461.52
Hs Code.:

Synonyms:(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

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Chemical Property of (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

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Technology Process of (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

There total 3 articles about (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 3958-60-9
2-nitrophenylmethyl bromide

: 884492-66-4
(S)-3-benzyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 1289116-77-3
(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

Guidance literature:: (S)-3-benzyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; With sodium hydride; In N,N-dimethyl-formamide; for 1.5h; Inert atmosphere;

2-nitrophenylmethyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.01.010

Reference yield:

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 1289116-77-3
(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3.1: ammonium acetate; acetic acid / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With ammonium acetate; sodium hydride; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.010

Reference yield:

: [1-(2-benzoyl-phenylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 1289116-77-3
(S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.1: ammonium acetate; acetic acid / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With ammonium acetate; sodium hydride; acetic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.010