[4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester

Base Information

• Chemical Name: [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester
• CAS No.: 1392490-56-0
• Molecular Formula: C₂₂H₂₅N₃O₅S
• Molecular Weight: 443.524
• Mol file: 1392490-56-0.mol

Synonyms:[4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester

Chemical Property of [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester

There total 6 articles about [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

N-[1-(4-aminobenzenesulfonyl)piperidin-4-yl]acrylamide (1392490-95-7) + benzyl chloroformate (501-53-1,94274-21-2) → [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester (1392490-56-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ml3001352

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester (1392490-56-0)

Guidance literature:

Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4: iron; ammonium chloride / water; ethanol / 3 h / 80 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1021/ml3001352

Reference yield:

N-[1-(4-nitrobenzenesulfonyl)piperidin-4-yl]acrylamide (1392490-94-6) → [4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester (1392490-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride / water; ethanol / 3 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water;

DOI:10.1021/ml3001352

upstream raw materials:

N-[1-(4-aminobenzenesulfonyl)piperidin-4-yl]acrylamide

benzyl chloroformate

4-Nitrobenzenesulfonyl chloride

N-[1-(4-nitrobenzenesulfonyl)piperidin-4-yl]acrylamide