104266-89-9

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 144-55-8 sodium hydrogencarbonate 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 3282-30-2 pivaloyl chloride 
• 65-85-0 benzoic acid 
• 888329-89-3 (S)-4-benzyl-3-(2-phenylethynyl)oxazolidin-2-one 
• 536-74-3 phenylacetylene 

Downstream Products

• 253680-94-3 [7-(4-benzyl-2-oxo-oxazolidin-3-yl)-5,7-dioxo-6-phenyl-heptyl]-carbamic acid tert-butyl ester 
• 170856-71-0 3-(1-oxo-2(S)-phenylpropyl)-4(S)-(phenymethyl)-2-oxazolidinone 
• 29125-25-5 (R)-2-azido-2-phenylacetic acid 
• 113543-52-5 benzyl 2(S)-azidophenylacetate 
• 113543-46-7 (3(2R),4S)-3-(2-azido-1-oxo-2-phenethyl)-4-(phenylmethyl)-2-oxazolidinone 
• 111525-67-8 (3(2S),4S)-3-(2-azido-2-phenyl-1-oxoethyl)-4-(phenylmethyl)-2-oxazolidinone 
• 113543-52-5 (R)-Azido-phenyl-acetic acid benzyl ester 
• 235097-99-1 (S)-4-benzyl-3-(2-phenylpent-4-enoyl)-2-oxazolidinone 
• 1225034-56-9 (S)-ethyl 4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate 
• 204851-68-3 (R)-3-Hydroxy-3-methyl-2-phenyl-butyric acid 
• 245323-38-0 (S)-4-(tert-butoxy)-4-oxo-2-phenylbutanoic acid 
• 245323-41-5 tert-butyl (3S)-N-(benzyloxycarbonyl)-3-amino-3-phenylpropanoate 
• 14441-08-8 (3S)-N-(benzyloxycarbonyl)-3-amino-3-phenylpropanoic acid 
• 253680-95-4 (S)-4-Benzyl-3-[2-phenyl-2-piperidin-(2Z)-ylidene-acetyl]-oxazolidin-2-one 

Relevant academic research and scientific papers

A method for synthesis of acylated oxazolidone

The invention discloses a method for synthesis of acylated oxazolidone. Synthesis method of the invention, comprising the following steps: in the non-protic organic solvent, the compound III and under the action of an acid, the compound I with compound II carries out amidation reaction, to obtain compound IV. The method of the invention can be conducted under mild conditions, high yield, high purity, and is suitable for industrial production requirements.

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

A green synthetic route to imides from terminal alkynes and amides by simple solid catalysts

An atom-efficient and green synthetic route to highly valuable imides (5492% yields) from terminal alkynes and amides has been developed. This new route is composed of two consecutive reactions, that is, (i) the reported Cu(OH)2-catalyzed cross-coupling o

Discovery of novel (S)-α-phenyl-γ-amino butanamide containing CCR5 antagonists via functionality inversion approach

By using functionality inversion approach, we identified a new scaffold containing (S)-α-phenyl-γ-amino butanamide as CCR5 antagonists derived from the 1,3-propanediamine carboxamide pharmacophore protocol. The (2S)-2-phenyl-4-(8-aza-bicyclo[3.2.1]octan-8

Stereoselective rearrangement of β-hydroxy-N-acyloxazolidin-2-ones to afford N-2-hydroxyethyl-1,3-oxazinane-2,4-diones

Zinc alkoxides of syn- or anti-β-hydroxy-N-acyloxazolidin-2-ones undergo stereoselective rearrangement to afford their corresponding syn- or anti-N-2-hydroxyethyl-1,3-oxazinane-2,4-diones in good yield.

DCC/DMAP-Mediated Coupling of Carboxylic Acids with Oxazolidinones and Thiazolidinethiones

Dicyclohexylcarbodiimide and catalytic dimethylaminopyridine were successfully used in the coupling of carboxylic acids with oxazolidinones and thiazolidinethiones. The acylated products were obtained in good yields.

Carboxy substituted acylic carboxamide derivatives

The present invention relates to novel carboxy substituted acyclic carboxamide derivatives of formula (1)): STR1and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

Benzamide potassium channel inhibitors

This invention relates to benzamide potassium channel inhibitors of general structural Formula I. The compounds of this invention are useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and related affl

SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) {1,4}DIAZEPAN-1-YL)-2-(ARYL)BUTYL) BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES

The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula: STR1 stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Enantioselective synthesis of (2S,2'R)-erythro-methylphenidate

A new approach towards the enantioselective synthesis of (2S,2'R)- erythro-methylphenidate (1) is described. The key step in the synthesis utilizes Evans' 4-substituted-2-oxazolidinone chiral auxiliary to control the diastereofacial selectivity in the hyd