1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Base Information

Chemical Name:1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide
CAS No.:1450923-31-5
Molecular Formula:C₂₆H₂₃ClF₃N₅O₄S₂
Molecular Weight:626.08
Hs Code.:

Synonyms:1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

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Chemical Property of 1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

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Technology Process of 1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

There total 6 articles about 1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450923-30-4
3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

: 106-93-4
ethylene dibromide

: 1450923-31-5
1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1450923-31-5
1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 0.75 h

1.2: 2 h / 20 - 34 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.03 h / Cooling with acetone-dry ice

2.2: 20 °C / Cooling with acetone-dry ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

4.1: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

5.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

With triisopropoxytitanium(IV) chloride; iron; caesium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1450923-29-1
4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-3-nitro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

: 1450923-31-5
1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

2: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

With iron; caesium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;