O-dibenzylretrodendrin

Base Information

• Chemical Name: O-dibenzylretrodendrin
• CAS No.: 111194-10-6
• Molecular Formula: C₃₄H₃₂O₆
• Molecular Weight: 536.624
• Mol file: 111194-10-6.mol

Synonyms:O-dibenzylretrodendrin

Chemical Property of O-dibenzylretrodendrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-dibenzylretrodendrin

There total 6 articles about O-dibenzylretrodendrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(3S,4R)-4-(4-Benzyloxy-3-methoxy-benzyl)-3-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-dihydro-furan-2-one (939963-12-9) → O-dibenzylretrodendrin (111194-10-6)

Guidance literature:

With perchloric acid; In dichloromethane; acetic acid; for 4.5h; Ambient temperature;

DOI:10.3987/R-1987-05-1169

Reference yield:

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → O-dibenzylretrodendrin (111194-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilylamide (LHDS) / 1.) benzene, 2.) benzene, 0 deg C, 5 min

2: 78 percent / 60percent aq. perchloric acid / acetic acid; CH₂Cl₂ / 4.5 h / Ambient temperature

With perchloric acid; lithium hexamethyldisilazane; In dichloromethane; acetic acid;

DOI:10.3987/R-1987-05-1169

Reference yield:

(R)-(+)-3-(4-benzyloxy-3-methoxybenzyl)-γ-butyrolactone (111266-03-6) → O-dibenzylretrodendrin (111194-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilylamide (LHDS) / 1.) benzene, 2.) benzene, 0 deg C, 5 min

2: 78 percent / 60percent aq. perchloric acid / acetic acid; CH₂Cl₂ / 4.5 h / Ambient temperature

With perchloric acid; lithium hexamethyldisilazane; In dichloromethane; acetic acid;

DOI:10.3987/R-1987-05-1169

upstream raw materials:

(3S,4R)-4-(4-Benzyloxy-3-methoxy-benzyl)-3-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-dihydro-furan-2-one

3-methoxy-4-(phenylmethoxy)benzaldehyde

(R)-(+)-3-(4-benzyloxy-3-methoxybenzyl)-γ-butyrolactone

benzyl chloride

Downstream raw materials:

O-dibenzylisolariciresinol

(6R,7R,8S)-isolariciresinol

Refernces