4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine

Base Information

• Chemical Name: 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine
• CAS No.: 229491-97-8
• Molecular Formula: C₁₉H₂₀N₂O₄S₂
• Molecular Weight: 404.511
• Mol file: 229491-97-8.mol

Synonyms:4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine

Chemical Property of 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine

There total 2 articles about 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 2-cyanoacetate (105-56-6) + 3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-1,2-thiazine-4-carbaldehyde (190202-08-5) → 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine (229491-97-8)

Guidance literature:

With acetic acid; triethylamine; In ethanol; for 24h; Ambient temperature;

DOI:10.1002/(sici)1521-3897(199905)341:4<403::aid-prac403>3.0.co;2-x

Reference yield: 37.0%

ethyl 2-cyanoacetate (105-56-6) + 3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-1,2-thiazine-4-carbaldehyde (190202-08-5) → 4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine (229491-97-8) + (2E,4E)-5-Amino-2-cyano-4-((Z)-1-methyl-2-methylsulfanyl-2-phenylsulfamoyl-vinyl)-hexa-2,4-dienoic acid ethyl ester

Guidance literature:

With ammonium hydroxide; ammonium acetate; In ethanol; for 72h;

DOI:10.1002/(sici)1521-3897(199905)341:4<403::aid-prac403>3.0.co;2-x

Reference yield: 53.0%

4-(2-ethoxycarbonyl-2-cyanovinyl)-3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-2H-1,2-thiazine (229491-97-8) → 7-amino-6-ethoxycarbonyl-4-methyl-3-methylthio-2,2-dioxo-1-phenyl-benzo-1,2-thiazine

Guidance literature:

With sodium ethanolate; In ethanol; for 24h;

DOI:10.1002/(sici)1521-3897(199905)341:4<403::aid-prac403>3.0.co;2-x

upstream raw materials:

ethyl 2-cyanoacetate

3,5-dimethyl-6-methylthio-1,1-dioxo-2-phenyl-1,2-thiazine-4-carbaldehyde