N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide
CAS No.:1609174-21-1
Molecular Formula:C₃₅H₄₁F₃N₄O₄
Molecular Weight:638.73
Hs Code.:

Synonyms:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

There total 12 articles about N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₂ClF₃N₂O₂

: 457060-96-7
2-butoxy-4-(3-(diethylamino)propoxy)aniline

: 1609174-21-1
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.03.072

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1609174-21-1
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper diacetate; triethylamine / dichloromethane / 24 h / 20 °C / Molecular sieve

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

4: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; copper diacetate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.03.072

Reference yield:

: C₁₈H₁₃F₃N₂O₃

: 1609174-21-1
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-1-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

2: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.072