4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine

Base Information

• Chemical Name: 4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine
• CAS No.: 1093626-01-7
• Molecular Formula: C₁₄H₁₆N₈
• Molecular Weight: 296.335

Synonyms:4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine

Chemical Property of 4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine

Chemical Property:

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Technology Process of 4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine

There total 1 articles about 4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-carbamic acid tert-butyl ester (1093626-00-6) → 4-methyl-N3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine (1093626-01-7)

Guidance literature:

{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

4-methyl-N3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine (1093626-01-7) + 3-(trifluoromethyl)benzoic acid (454-92-2) → N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide (1093625-97-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzenamine (884603-40-1) + bis(trichloromethyl) carbonate (32315-10-9) + 4-methyl-N3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine (1093626-01-7) → 1-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-3-(3-pyrrolidin-1-ylmethyl-5-trifluoromethyl-phenyl)-urea (1093626-09-5)

Guidance literature:

bis(trichloromethyl) carbonate; 4-methyl-N₃-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-yl]-benzene-1,3-diamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzenamine; In dichloromethane; at 20 ℃; for 0.533333h;

upstream raw materials:

{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-carbamic acid tert-butyl ester

Downstream raw materials:

1-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-3-(3-pyrrolidin-1-ylmethyl-5-trifluoromethyl-phenyl)-urea

N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide

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