N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

• Chemical Name: N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
• CAS No.: 898221-45-9
• Molecular Formula: C₁₈H₁₉N₅O₆
• Molecular Weight: 401.379
• Mol file: 898221-45-9.mol

Synonyms:N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property of N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 1 articles about N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(6-benzoylamino-purin-9-yl)-5-((R)-1,2-diacetoxy-ethyl)-tetrahydro-furan-3-yl ester → N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (898221-45-9)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2004.09.051

Reference yield: 70.0%

2,2-dimethoxy-propane (77-76-9) + N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (898221-45-9) → N6-benzoyl-2',3'-O-isopropylidene-9-(β-D-allofuranosyl)adenine (812644-08-9)

Guidance literature:

2,2-dimethoxy-propane; N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide; With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In acetone;

With acetic acid; In acetone;

DOI:10.1016/j.bmcl.2004.09.051

Reference yield:

N-{9-[(2R,3R,4S,5R)-5-((R)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (898221-45-9) → N-[9-((2R,3R,4S,5S)-3,4-Dihydroxy-5-(S)-thiiranyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:

Multi-step reaction with 6 steps

1.1: APTS / acetone

1.2: 70 percent / aq. AcOH / acetone

2.1: imidazole; pyridine

3.1: pyridine

4.1: TBAF / tetrahydrofuran

5.1: thiourea / methanol

6.1: aq. CH₃CO₂H

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; thiourea; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/j.bmcl.2004.09.051

Downstream raw materials:

N⁶-benzoyl-2',3'-O-isopropylidene-9-(β-D-allofuranosyl)adenine

N-[9-(2,2-dimethyl-6-thiiranyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

N-[9-(2,2-dimethyl-6-oxiranyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

N-[9-(2,2-dimethyl-6-oxiranyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide