2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol

Base Information

• Chemical Name: 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol
• CAS No.: 1429785-97-6
• Molecular Formula: C₁₅H₁₈IN₃O₃
• Molecular Weight: 415.231
• Mol file: 1429785-97-6.mol

Synonyms:2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol

Chemical Property of 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol

There total 4 articles about 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl 2-(3-iodo-4,5-dimethoxybenzyl)-3-oxopentanoate (1429785-94-3) + diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) → 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol (1429785-97-6)

Guidance literature:

ethyl 2-(3-iodo-4,5-dimethoxybenzyl)-3-oxopentanoate; diguanidine carbonate; With sodium methylate; In ethanol; at 0 - 78 ℃; Inert atmosphere;

With water; In ethanol; at 0 ℃;

DOI:10.1002/cmdc.201200291

Reference yield: 78.0%

→ 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol (1429785-97-6)

Guidance literature:

In ethanol; for 18h; Reflux;

Reference yield:

(3-iodo-4,5-dimethoxyphenyl)methanol (773869-09-3) → 2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol (1429785-97-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorus tribromide / diethyl ether / 0.83 h / 0 - 23 °C / Inert atmosphere

2.1: sodium methylate / ethanol / 50 °C / Inert atmosphere

2.2: 78 °C / Inert atmosphere

3.1: sodium methylate / ethanol / 0 - 78 °C / Inert atmosphere

3.2: 0 °C

With sodium methylate; phosphorus tribromide; In diethyl ether; ethanol;

DOI:10.1002/cmdc.201200291

upstream raw materials:

ethyl 2-(3-iodo-4,5-dimethoxybenzyl)-3-oxopentanoate

diguanidine carbonate

5-iodovaniline

(3-iodo-4,5-dimethoxyphenyl)methanol

Downstream raw materials:

5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidine-2,4-diamine

5-(3-iodo-4,5-dimethoxybenzyl)-6-propylpyrimidine-2,4-diamine

(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

(E)-3-(5-((2,4-diamino-6-propylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(1-propyl-phthalazin-2(1H)-yl)prop-2-en-1-one